2ARW

The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor

2ARW の概要

• エントリーDOI: 10.2210/pdb2arw/pdb
• NMR情報: BMRB: 5940
• 分子名称: Interleukin-6 receptor alpha chain (1 entity in total)
• 機能のキーワード: fibronectin-type iii like, cytokine
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14680.38

構造登録者

Hecht, O.,Dingley, A.J.,Schwantner, A.,Ozbek, S.,Rose-John, S.,Grotzinger, J. (登録日: 2005-08-22, 公開日: 2006-09-12, 最終更新日: 2024-05-01)

主引用文献

Hecht, O.,Dingley, A.J.,Schwanter, A.,Ozbek, S.,Rose-John, S.,Grotzinger, J.
The solution structure of the membrane-proximal cytokine receptor domain of the human interleukin-6 receptor
Biol.Chem., 387:1255-1259, 2006

PubMed Abstract: The members of the interleukin-6-type family of cytokines interact with receptors that have a modular structure and are built of several immunoglobulin-like and fibronectin type III-like domains. These receptors have a characteristic cytokine receptor homology region consisting of two fibronectin type III-like domains defined by a set of four conserved cysteines and a tryptophan-serine-X-tryptophan-serine sequence motif. On target cells, interleukin-6 (IL-6) initially binds to its cognate alpha-receptor and subsequently to a homodimer of the signal transducer receptor gp130. The IL-6 receptor (IL-6R) consists of three extracellular domains. The N-terminal immunoglobulin-like domain is not involved in ligand binding, whereas the third membrane-proximal fibronectin-like domain (IL-6R-D3) accounts for more than 90% of the binding energy to IL-6. Here, we present the solution structure of the IL-6R-D3 domain solved by multidimensional heteronuclear NMR spectroscopy.

PubMed: 16972794
DOI: 10.1515/BC.2006.155

実験手法

SOLUTION NMR