2ARQ

Human plasminogen activator inhibitor-2.[loop (66-98) deletion mutant] complexed with peptide n-acetyl-teaaagdggvmtgr-oh

Summary for 2ARQ

• Entry DOI: 10.2210/pdb2arq/pdb
• Related: 1JRR 2ARR
• Descriptor: Plasminogen activator inhibitor-2, 14-mer from Plasminogen activator inhibitor-2 (3 entities in total)
• Functional Keywords: serpin, peptide binding, inhibitor, hydrolase inhibitor-peptide complex, hydrolase inhibitor/peptide
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P05120 P05120
• Total number of polymer chains: 2
• Total formula weight: 44306.34

Authors

Di Giusto, D.A.,Sutherland, A.P.,Jankova, L.,Harrop, S.J.,Curmi, P.M.,King, G.C. (deposition date: 2005-08-21, release date: 2006-07-11, Last modification date: 2023-10-25)

• Primary citation: Di Giusto, D.A.,Sutherland, A.P.,Jankova, L.,Harrop, S.J.,Curmi, P.M.,King, G.C.; Plasminogen activator inhibitor-2 is highly tolerant to P8 residue substitution--implications for serpin mechanistic model and prediction of nsSNP activities; J.Mol.Biol., 353:1069-1080, 2005; PubMed: 16214170; DOI: 10.1016/j.jmb.2005.09.008

Experimental method

X-RAY DIFFRACTION (1.85 Å)