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2AQB

Structure-activity relationships at the 5-position of thiolactomycin: an intact 5(R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherchia coli

Summary for 2AQB
Entry DOI10.2210/pdb2aqb/pdb
Related1FJ4 2AQ7
Descriptor3-oxoacyl-[acyl-carrier-protein] synthase I, (5R)-5-[(1E)-BUTA-1,3-DIENYL]-4-HYDROXY-3,5-DIMETHYLTHIOPHEN-2(5H)-ONE (3 entities in total)
Functional Keywordsfabb-ligand active-site complex, transferase
Biological sourceEscherichia coli
Cellular locationCytoplasm: P0A953
Total number of polymer chains4
Total formula weight171213.61
Authors
Kim, P.,Zhang, Y.M.,Shenoy, G.,Nguyen, Q.A.,Boshoff, H.I.,Manjunatha, U.H.,Goodwin, M.B.,Lonsdale, J.,Price, A.C.,Miller, D.J. (deposition date: 2005-08-17, release date: 2006-01-17, Last modification date: 2023-08-23)
Primary citationKim, P.,Zhang, Y.M.,Shenoy, G.,Nguyen, Q.A.,Boshoff, H.I.,Manjunatha, U.H.,Goodwin, M.B.,Lonsdale, J.,Price, A.C.,Miller, D.J.,Duncan, K.,White, S.W.,Rock, C.O.,Barry III, C.E.,Dowd, C.S.
Structure-Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli
J.Med.Chem., 49:159-171, 2006
Cited by
PubMed: 16392800
DOI: 10.1021/jm050825p
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.19 Å)
Structure validation

217705

건을2024-03-27부터공개중

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