2AQ7
Structure-activity relationships at the 5-posiiton of thiolactomycin: an intact 5(R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli
Summary for 2AQ7
Entry DOI | 10.2210/pdb2aq7/pdb |
Related | 1FJ4 |
Descriptor | 3-oxoacyl-[acyl-carrier-protein] synthase I, (5R)-4-HYDROXY-3,5-DIMETHYL-5-[(1E,3E)-2-METHYLPENTA-1,3-DIENYL]THIOPHEN-2(5H)-ONE (3 entities in total) |
Functional Keywords | fabb-ligand active-site complex, transferase |
Biological source | Escherichia coli |
Cellular location | Cytoplasm: P0A953 |
Total number of polymer chains | 4 |
Total formula weight | 171297.77 |
Authors | Kim, P.,Zhang, Y.M.,Shenoy, G.,Nguyen, Q.A.,Boshoff, H.I.,Manjunatha, U.H.,Goodwin, M.B.,Lonsdale, J.,Price, A.C.,Miller, D.J. (deposition date: 2005-08-17, release date: 2006-01-17, Last modification date: 2023-08-23) |
Primary citation | Kim, P.,Zhang, Y.M.,Shenoy, G.,Nguyen, Q.A.,Boshoff, H.I.,Manjunatha, U.H.,Goodwin, M.B.,Lonsdale, J.,Price, A.C.,Miller, D.J.,Duncan, K.,White, S.W.,Rock, C.O.,Barry III, C.E.,Dowd, C.S. Structure-Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli J.Med.Chem., 49:159-171, 2006 Cited by PubMed: 16392800DOI: 10.1021/jm050825p PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
Download full validation report