2AQ7

Structure-activity relationships at the 5-posiiton of thiolactomycin: an intact 5(R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli

2AQ7 の概要

• エントリーDOI: 10.2210/pdb2aq7/pdb
• 関連するPDBエントリー: 1FJ4
• 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase I, (5R)-4-HYDROXY-3,5-DIMETHYL-5-[(1E,3E)-2-METHYLPENTA-1,3-DIENYL]THIOPHEN-2(5H)-ONE (3 entities in total)
• 機能のキーワード: fabb-ligand active-site complex, transferase
• 由来する生物種: Escherichia coli
• 細胞内の位置: Cytoplasm: P0A953
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 171297.77

構造登録者

Kim, P.,Zhang, Y.M.,Shenoy, G.,Nguyen, Q.A.,Boshoff, H.I.,Manjunatha, U.H.,Goodwin, M.B.,Lonsdale, J.,Price, A.C.,Miller, D.J. (登録日: 2005-08-17, 公開日: 2006-01-17, 最終更新日: 2023-08-23)

• 主引用文献: Kim, P.,Zhang, Y.M.,Shenoy, G.,Nguyen, Q.A.,Boshoff, H.I.,Manjunatha, U.H.,Goodwin, M.B.,Lonsdale, J.,Price, A.C.,Miller, D.J.,Duncan, K.,White, S.W.,Rock, C.O.,Barry III, C.E.,Dowd, C.S.; Structure-Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli; J.Med.Chem., 49:159-171, 2006; PubMed: 16392800; DOI: 10.1021/jm050825p

実験手法

X-RAY DIFFRACTION (2.3 Å)