2APQ

Crystal Structure of an Active Site Mutant of Bovine Pancreatic Ribonuclease A (H119A-RNase A) with a 10-Glutamine expansion in the C-terminal hinge-loop.

2APQ の概要

• エントリーDOI: 10.2210/pdb2apq/pdb
• 関連するPDBエントリー: 1fs3
• 分子名称: Ribonuclease, PHOSPHATE ION (3 entities in total)
• 機能のキーワード: an active site mutant of rnase a (h119a) with an amyloidogenic expansion in the c-terminal hinge-loop region(between residues 112 and 113)., hydrolase
• 由来する生物種: Bos taurus (cattle)
• 細胞内の位置: Secreted: P61823
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15499.94

構造登録者

Sambashivan, S.,Liu, Y.,Sawaya, M.R.,Gingery, M.,Eisenberg, D. (登録日: 2005-08-16, 公開日: 2005-09-13, 最終更新日: 2023-08-23)

• 主引用文献: Sambashivan, S.,Liu, Y.,Sawaya, M.R.,Gingery, M.,Eisenberg, D.; Amyloid-like fibrils of ribonuclease A with three-dimensional domain-swapped and native-like structure.; Nature, 437:266-269, 2005; PubMed: 16148936; DOI: 10.1038/nature03916

実験手法

X-RAY DIFFRACTION (1.8 Å)