2AOA

Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain

2AOA の概要

分子名称Growth factor receptor-bound protein 2, 2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, ... (4 entities in total)
機能のキーワードgrb2 sh2, domain-swapped, peptide mimetic, transferase
由来する生物種Homo sapiens (human)
細胞内の位置Nucleus  P62993
ポリマー鎖数2
分子量合計25741.17
構造登録者
Phan, J.,Shi, Z.D.,Burke, T.R.,Waugh, D.S. (登録日: 2005-08-12, 公開日: 2005-10-04, 最終更新日: 2017-10-11)
主引用文献
Phan, J.,Shi, Z.D.,Burke, T.R.,Waugh, D.S.
Crystal Structures of a High-affinity Macrocyclic Peptide Mimetic in Complex with the Grb2 SH2 Domain.
J.Mol.Biol., 353:104-115, 2005
PubMed: 16165154 (主引用文献が同じPDBエントリー)
DOI: 10.1016/j.jmb.2005.08.037
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (1.99 Å)
NMR情報
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構造検証レポート

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers251.2%16.5%11.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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