2ANY

Expression, Crystallization and the Three-dimensional Structure of the Catalytic Domain of Human Plasma Kallikrein: Implications for Structure-Based Design of Protease Inhibitors

Summary for 2ANY

Entry DOI	10.2210/pdb2any/pdb
Related	2ANW
Descriptor	plasma kallikrein, light chain, PHOSPHATE ION, BENZAMIDINE, ... (4 entities in total)
Functional Keywords	mutagenically deglycosyalted human plasma kallikrein protease domain; trypsin-like serine protease, blood clotting, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Secreted: P03952
Total number of polymer chains	1
Total formula weight	27549.91
Authors	Tang, J.,Yu, C.L.,Williams, S.R.,Springman, E.,Jeffery, D.,Sprengeler, P.A.,Estevez, A.,Sampang, J.,Shrader, W.,Spencer, J.R.,Young, W.B.,McGrath, M.E.,Katz, B.A. (deposition date: 2005-08-11, release date: 2005-10-11, Last modification date: 2023-08-23)
Primary citation	Tang, J.,Yu, C.L.,Williams, S.R.,Springman, E.,Jeffery, D.,Sprengeler, P.A.,Estevez, A.,Sampang, J.,Shrader, W.,Spencer, J.,Young, W.,McGrath, M.,Katz, B.A. Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein. J.Biol.Chem., 280:41077-41089, 2005 Cited by PubMed: 16199530 DOI: 10.1074/jbc.M506766200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation