2ANW

Expression, crystallization and three-dimensional structure of the catalytic domain of human plasma kallikrein: Implications for structure-based design of protease inhibitors

Summary for 2ANW

Entry DOI	10.2210/pdb2anw/pdb
Related	2ANY
Descriptor	plasma kallikrein, light chain, BENZAMIDINE (3 entities in total)
Functional Keywords	trypsin-like serine protease; enzymatically deglycosylated, blood clotting, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Secreted: P03952
Total number of polymer chains	1
Total formula weight	27219.96
Authors	Tang, J.,Yu, C.L.,Williams, S.R.,Springman, E.,Jeffery, D.,Sprengeler, P.A.,Estevez, A.,Sampang, J.,Shrader, W.,Spencer, J.R.,Young, W.B.,McGrath, M.E.,Katz, B.A. (deposition date: 2005-08-11, release date: 2005-10-11, Last modification date: 2023-08-23)
Primary citation	Tang, J.,Yu, C.L.,Williams, S.R.,Springman, E.,Jeffery, D.,Sprengeler, P.A.,Estevez, A.,Sampang, J.,Shrader, W.,Spencer, J.,Young, W.,McGrath, M.,Katz, B.A. Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein. J.Biol.Chem., 280:41077-41089, 2005 Cited by PubMed: 16199530 DOI: 10.1074/jbc.M506766200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation