2ANW

Expression, crystallization and three-dimensional structure of the catalytic domain of human plasma kallikrein: Implications for structure-based design of protease inhibitors

2ANW の概要

• エントリーDOI: 10.2210/pdb2anw/pdb
• 関連するPDBエントリー: 2ANY
• 分子名称: plasma kallikrein, light chain, BENZAMIDINE (3 entities in total)
• 機能のキーワード: trypsin-like serine protease; enzymatically deglycosylated, blood clotting, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P03952
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27219.96

構造登録者

Tang, J.,Yu, C.L.,Williams, S.R.,Springman, E.,Jeffery, D.,Sprengeler, P.A.,Estevez, A.,Sampang, J.,Shrader, W.,Spencer, J.R.,Young, W.B.,McGrath, M.E.,Katz, B.A. (登録日: 2005-08-11, 公開日: 2005-10-11, 最終更新日: 2023-08-23)

• 主引用文献: Tang, J.,Yu, C.L.,Williams, S.R.,Springman, E.,Jeffery, D.,Sprengeler, P.A.,Estevez, A.,Sampang, J.,Shrader, W.,Spencer, J.,Young, W.,McGrath, M.,Katz, B.A.; Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein.; J.Biol.Chem., 280:41077-41089, 2005; PubMed: 16199530; DOI: 10.1074/jbc.M506766200

実験手法

X-RAY DIFFRACTION (1.85 Å)