2AMV

THE STRUCTURE OF GLYCOGEN PHOSPHORYLASE B WITH AN ALKYL-DIHYDROPYRIDINE-DICARBOXYLIC ACID

「1AMV」から置き換えられました

2AMV の概要

• エントリーDOI: 10.2210/pdb2amv/pdb
• 分子名称: PROTEIN (GLYCOGEN PHOSPHORYLASE), PYRIDOXAL-5'-PHOSPHATE, 2,3-DICARBOXY-4-(2-CHLORO-PHENYL)-1-ETHYL-5-ISOPROPOXYCARBONYL-6-METHYL-PYRIDINIUM, ... (5 entities in total)
• 機能のキーワード: glycogen phosphorylase, glycogen metabolism, diabetes, inhibitors, glycosyltransferase, transferase
• 由来する生物種: Oryctolagus cuniculus (rabbit)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 98037.28

構造登録者

Zographos, S.E.,Oikonomakos, N.G.,Johnson, L.N. (登録日: 1998-10-13, 公開日: 1998-10-21, 最終更新日: 2025-03-26)

主引用文献

Zographos, S.E.,Oikonomakos, N.G.,Tsitsanou, K.E.,Leonidas, D.D.,Chrysina, E.D.,Skamnaki, V.T.,Bischoff, H.,Goldmann, S.,Watson, K.A.,Johnson, L.N.
The structure of glycogen phosphorylase b with an alkyldihydropyridine-dicarboxylic acid compound, a novel and potent inhibitor.
Structure, 5:1413-1425, 1997

PubMed Abstract: In muscle and liver, glycogen concentrations are regulated by the reciprocal activities of glycogen phosphorylase (GP) and glycogen synthase. An alkyl-dihydropyridine-dicarboxylic acid has been found to be a potent inhibitor of GP, and as such has potential to contribute to the regulation of glycogen metabolism in the non-insulin-dependent diabetes diseased state. The inhibitor has no structural similarity to the natural regulators of GP. We have carried out structural studies in order to elucidate the mechanism of inhibition.

PubMed: 9384557
DOI: 10.1016/S0969-2126(97)00292-X

実験手法

X-RAY DIFFRACTION (2.3 Å)