2AMT

Structure of 2C-Methyl-D-Erythritol 2,4-Clycodiphosphate Synthase complexed with a CDP derived fluorescent inhibitor

Summary for 2AMT

Entry DOI	10.2210/pdb2amt/pdb
Related	1GX1 1KNJ 1U3P 2AO4
Descriptor	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, ZINC ION, 5'-O-[({[(2-{[(2-AMINOPHENYL)CARBONYL]OXY}ETHYL)OXY]PHOSPHINATO}OXY)PHOSPHINATO]CYTIDINE, ... (5 entities in total)
Functional Keywords	isoprenoid, lyase, isoprene biosynthesis
Biological source	Escherichia coli
Total number of polymer chains	6
Total formula weight	105942.16
Authors	Ramsden, N.L.,Hunter, W.N. (deposition date: 2005-08-10, release date: 2006-02-28, Last modification date: 2023-08-23)
Primary citation	Crane, C.M.,Kaiser, J.,Ramsden, N.L.,Lauw, S.,Rohdich, F.,Eisenreich, W.,Hunter, W.N.,Bacher, A.,Diederich, F. Fluorescent Inhibitors for IspF, an Enzyme in the Non-Mevalonate Pathway for Isoprenoid Biosynthesis and a Potential Target for Antimalarial Therapy. Angew.Chem.Int.Ed.Engl., 45:1069-1074, 2006 Cited by PubMed: 16392111 DOI: 10.1002/anie.200503003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation