2AMT

Structure of 2C-Methyl-D-Erythritol 2,4-Clycodiphosphate Synthase complexed with a CDP derived fluorescent inhibitor

2AMT の概要

• エントリーDOI: 10.2210/pdb2amt/pdb
• 関連するPDBエントリー: 1GX1 1KNJ 1U3P 2AO4
• 分子名称: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, ZINC ION, 5'-O-[({[(2-{[(2-AMINOPHENYL)CARBONYL]OXY}ETHYL)OXY]PHOSPHINATO}OXY)PHOSPHINATO]CYTIDINE, ... (5 entities in total)
• 機能のキーワード: isoprenoid, lyase, isoprene biosynthesis
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 105942.16

構造登録者

Ramsden, N.L.,Hunter, W.N. (登録日: 2005-08-10, 公開日: 2006-02-28, 最終更新日: 2023-08-23)

• 主引用文献: Crane, C.M.,Kaiser, J.,Ramsden, N.L.,Lauw, S.,Rohdich, F.,Eisenreich, W.,Hunter, W.N.,Bacher, A.,Diederich, F.; Fluorescent Inhibitors for IspF, an Enzyme in the Non-Mevalonate Pathway for Isoprenoid Biosynthesis and a Potential Target for Antimalarial Therapy.; Angew.Chem.Int.Ed.Engl., 45:1069-1074, 2006; PubMed: 16392111; DOI: 10.1002/anie.200503003

実験手法

X-RAY DIFFRACTION (2.3 Å)