2AI3
Purine nucleoside phosphorylase from calf spleen
Summary for 2AI3
| Entry DOI | 10.2210/pdb2ai3/pdb |
| Related | 2AI1 2AI2 |
| Descriptor | Purine nucleoside phosphorylase, MAGNESIUM ION, ZINC ION, ... (6 entities in total) |
| Functional Keywords | purine nucleoside phosphorylase, multisubstrate analog inhibitor, transferase |
| Biological source | Bos taurus (cattle) |
| Cellular location | Cytoplasm, cytoskeleton (By similarity): P55859 |
| Total number of polymer chains | 1 |
| Total formula weight | 32714.63 |
| Authors | Toms, A.V.,Wang, W.,Li, Y.,Ganem, B.,Ealick, S.E. (deposition date: 2005-07-28, release date: 2005-10-25, Last modification date: 2023-08-23) |
| Primary citation | Toms, A.V.,Wang, W.,Li, Y.,Ganem, B.,Ealick, S.E. Novel multisubstrate inhibitors of mammalian purine nucleoside phosphorylase. Acta Crystallogr.,Sect.D, 61:1449-1458, 2005 Cited by PubMed Abstract: In an effort to develop potent multisubstrate-analog inhibitors of purine nucleoside phosphorylase (PNP), three nucleoside phosphonates were designed utilizing structural information from the previously reported structures of complexes of bovine PNP with substrates and products. The nucleoside phosphonates contain an acetal linkage at the O2' and O3' positions and a two-C-atom spacer between the ribose and phosphate moieties. The linkage enables the compounds to simultaneously occupy the purine-, ribose- and phosphate-binding sites. The chemical syntheses, inhibition profiles and structural characterization of these novel multisubstrate analog inhibitors with bovine PNP are described. PubMed: 16239721DOI: 10.1107/S0907444905025503 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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