2AFU

Crystal structure of human glutaminyl cyclase in complex with glutamine t-butyl ester

Summary for 2AFU

Entry DOI	10.2210/pdb2afu/pdb
Related	2AFO 2AFS 2AFW 2AFX 2AFZ
Descriptor	Glutaminyl-peptide cyclotransferase, ZINC ION, TERT-BUTYL D-ALPHA-GLUTAMINATE, ... (4 entities in total)
Functional Keywords	alpha-beta protein, metalloprotein, transferase
Biological source	Homo sapiens (human)
Cellular location	Secreted: Q16769
Total number of polymer chains	2
Total formula weight	75648.15
Authors	Huang, K.F.,Liu, Y.L.,Cheng, W.J.,Ko, T.P.,Wang, A.H.J. (deposition date: 2005-07-26, release date: 2005-08-23, Last modification date: 2021-11-10)
Primary citation	Huang, K.F.,Liu, Y.L.,Cheng, W.J.,Ko, T.P.,Wang, A.H. Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation Proc.Natl.Acad.Sci.Usa, 102:13117-13122, 2005 Cited by PubMed: 16135565 DOI: 10.1073/pnas.0504184102 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.22 Å)

Structure validation