2AE7

Crystal Structure of Human M340H-Beta1,4-Galactosyltransferase-I (M340H-B4GAL-T1) in Complex with Pentasaccharide

Summary for 2AE7

Entry DOI	10.2210/pdb2ae7/pdb
Related	1O0R 1TVY 1TW1 1TW5 2AEC 2AES 2AGD 2AH9
Descriptor	Beta-1,4-galactosyltransferase 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose, ... (9 entities in total)
Functional Keywords	beta1, 4-galactosyltransferase-i; pentasaccharide; closed conformation; mutant, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	3
Total formula weight	103384.34
Authors	Ramasamy, V.,Ramakrishnan, B.,Boeggeman, E.,Ratner, D.M.,Seeberger, P.H.,Qasba, P.K. (deposition date: 2005-07-21, release date: 2005-10-04, Last modification date: 2023-08-23)
Primary citation	Ramasamy, V.,Ramakrishnan, B.,Boeggeman, E.,Ratner, D.M.,Seeberger, P.H.,Qasba, P.K. Oligosaccharide Preferences of beta1,4-Galactosyltransferase-I: Crystal Structures of Met340His Mutant of Human beta1,4-Galactosyltransferase-I with a Pentasaccharide and Trisaccharides of the N-Glycan Moiety J.Mol.Biol., 353:53-67, 2005 Cited by PubMed: 16157350 DOI: 10.1016/j.jmb.2005.07.050 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation