2ABL

SH3-SH2 DOMAIN FRAGMENT OF HUMAN BCR-ABL TYROSINE KINASE

2ABL の概要

• エントリーDOI: 10.2210/pdb2abl/pdb
• 分子名称: ABL TYROSINE KINASE (2 entities in total)
• 機能のキーワード: transferase, tyrosine kinase, sh3, sh2, oncoprotein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor: P00519
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18122.95

構造登録者

Nam, H.-J.,Frederick, C.A. (登録日: 1996-11-17, 公開日: 1997-09-04, 最終更新日: 2024-04-03)

主引用文献

Nam, H.J.,Haser, W.G.,Roberts, T.M.,Frederick, C.A.
Intramolecular interactions of the regulatory domains of the Bcr-Abl kinase reveal a novel control mechanism.
Structure, 4:1105-1114, 1996

PubMed Abstract: The Abl nonreceptor tyrosine kinase is implicated in a range of cellular processes and its transforming variants are involved in human leukemias. The N-terminal regulatory region of the Abl protein contains Src homology domains SH2 and SH3 which have been shown to be important for the regulation of its activity in vivo. These domains are often found together in the same protein and biochemical data suggest that the functions of one domain can be influenced by the other.

PubMed: 8805596
DOI: 10.1016/S0969-2126(96)00116-5

実験手法

X-RAY DIFFRACTION (2.5 Å)