2A7S

Crystal Structure of the Acyl-CoA Carboxylase, AccD5, from Mycobacterium tuberculosis

Summary for 2A7S

Entry DOI	10.2210/pdb2a7s/pdb
Descriptor	Probable propionyl-CoA carboxylase beta chain 5 (2 entities in total)
Functional Keywords	carboxylase, carboxyltransferase, acetyl-coa carboxylase, propionyl-coa carboxylase, acyl-coa carboxylase, mycolic acid, fatty acid, polyketide, ligase
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	6
Total formula weight	356519.81
Authors	Lin, T.,Melgar, M.,Purdon, J.,Tseng, T.,Tsai, S.C. (deposition date: 2005-07-06, release date: 2006-02-21, Last modification date: 2024-04-03)
Primary citation	Lin, T.W.,Melgar, M.M.,Kurth, D.,Swamidass, S.J.,Purdon, J.,Tseng, T.,Gago, G.,Baldi, P.,Gramajo, H.,Tsai, S.C. Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis. Proc.Natl.Acad.Sci.Usa, 103:3072-3077, 2006 Cited by PubMed: 16492739 DOI: 10.1073/pnas.0510580103 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation