2A79

Mammalian Shaker Kv1.2 potassium channel- beta subunit complex

2A79 の概要

• エントリーDOI: 10.2210/pdb2a79/pdb
• 関連するPDBエントリー: 1EXB
• 分子名称: Voltage-gated potassium channel beta-2 subunit, Potassium voltage-gated channel subfamily A member 2, poly-unknown chain, ... (7 entities in total)
• 機能のキーワード: potassium channel, voltage sensor, voltage dependent, ion channel, shaker, membrane protein, eukaryotic, kv1.2
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• 細胞内の位置: Cytoplasm (Potential): P62483; Membrane; Multi-pass membrane protein: P63142
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 101329.20

構造登録者

Long, S.B.,Campbell, E.B.,MacKinnon, R. (登録日: 2005-07-05, 公開日: 2005-07-12, 最終更新日: 2023-08-23)

主引用文献

Long, S.B.,Campbell, E.B.,Mackinnon, R.
Crystal structure of a mammalian voltage-dependent Shaker family K+ channel.
Science, 309:897-903, 2005

PubMed Abstract: Voltage-dependent potassium ion (K+) channels (Kv channels) conduct K+ ions across the cell membrane in response to changes in the membrane voltage, thereby regulating neuronal excitability by modulating the shape and frequency of action potentials. Here we report the crystal structure, at a resolution of 2.9 angstroms, of a mammalian Kv channel, Kv1.2, which is a member of the Shaker K+ channel family. This structure is in complex with an oxido-reductase beta subunit of the kind that can regulate mammalian Kv channels in their native cell environment. The activation gate of the pore is open. Large side portals communicate between the pore and the cytoplasm. Electrostatic properties of the side portals and positions of the T1 domain and beta subunit are consistent with electrophysiological studies of inactivation gating and with the possibility of K+ channel regulation by the beta subunit.

PubMed: 16002581
DOI: 10.1126/science.1116269

実験手法

X-RAY DIFFRACTION (2.9 Å)