2A62

Crystal structure of mouse cadherin-8 EC1-3

2A62 の概要

• エントリーDOI: 10.2210/pdb2a62/pdb
• 関連するPDBエントリー: 1zvn 1zxk 2a4c 2a4e
• 分子名称: Cadherin-8, CALCIUM ION (2 entities in total)
• 機能のキーワード: cadherin, extracellular domain, homodimer, calcium binding, cell adhesion
• 由来する生物種: Mus musculus (house mouse)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein: P97291
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35540.81

構造登録者

Patel, S.D.,Ciatto, C.,Chen, C.P.,Bahna, F.,Arkus, N.,Schieren, I.,Jessell, T.M.,Honig, B.,Price, S.R.,Shapiro, L. (登録日: 2005-07-01, 公開日: 2006-04-25, 最終更新日: 2024-02-14)

主引用文献

Patel, S.D.,Ciatto, C.,Chen, C.P.,Bahna, F.,Rajebhosale, M.,Arkus, N.,Schieren, I.,Jessell, T.M.,Honig, B.,Price, S.R.,Shapiro, L.
Type II cadherin ectodomain structures: implications for classical cadherin specificity.
Cell(Cambridge,Mass.), 124:1255-1268, 2006

PubMed Abstract: Type I and II classical cadherins help to determine the adhesive specificities of animal cells. Crystal-structure determination of ectodomain regions from three type II cadherins reveals adhesive dimers formed by exchange of N-terminal beta strands between partner extracellular cadherin-1 (EC1) domains. These interfaces have two conserved tryptophan side chains that anchor each swapped strand, compared with one in type I cadherins, and include large hydrophobic regions unique to type II interfaces. The EC1 domains of type I and type II cadherins appear to encode cell adhesive specificity in vitro. Moreover, perturbation of motor neuron segregation with chimeric cadherins depends on EC1 domain identity, suggesting that this region, which includes the structurally defined adhesive interface, encodes type II cadherin functional specificity in vivo.

PubMed: 16564015
DOI: 10.1016/j.cell.2005.12.046

実験手法

X-RAY DIFFRACTION (4.5 Å)