2A4F

Synthesis and Activity of N-Axyl Azacyclic Urea HIV-1 Protease Inhibitors with High Potency Against Multiple Drug Resistant Viral Strains.

2A4F の概要

• エントリーDOI: 10.2210/pdb2a4f/pdb
• 関連するPDBエントリー: 1YT9
• 分子名称: Pol polyprotein, (5R,6R)-5-BENZYL-6-HYDROXY-2,4-BIS(4-HYDROXY-3-METHOXYBENZYL)-1-[3-(4-HYDROXYPHENYL)PROPANOYL]-1,2,4-TRIAZEPAN-3-ONE (3 entities in total)
• 機能のキーワード: hiv protease, aza-cyclic urea, hydrolase
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22249.22

構造登録者

Zhao, C.,Sham, H.,Sun, M.,Lin, S.,Stoll, V.,Stewart, K.D.,Mo, H.,Vasavanonda, S.,Saldivar, A.,McDonald, E. (登録日: 2005-06-28, 公開日: 2005-09-20, 最終更新日: 2024-02-14)

主引用文献

Zhao, C.,Sham, H.L.,Sun, M.,Stoll, V.S.,Stewart, K.D.,Lin, S.,Mo, H.,Vasavanonda, S.,Saldivar, A.,Park, C.,McDonald, E.J.,Marsh, K.C.,Klein, L.L.,Kempf, D.J.,Norbeck, D.W.
Synthesis and activity of N-acyl azacyclic urea HIV-1 protease inhibitors with high potency against multiple drug resistant viral strains
Bioorg.Med.Chem.Lett., 15:5499-5503, 2005

PubMed Abstract: As part of our efforts to identify potent HIV-1 protease inhibitors that are active against resistant viral strains, structural modification of the azacyclic urea (I) was undertaken by incorporating acyl groups as P(1)' ligands. The extensive SAR study has yielded a series of N-acyl azacyclic ureas (II), which are highly potent against both wild-type and multiple PI-resistant viral strains.

PubMed: 16203141
DOI: 10.1016/j.bmcl.2005.08.093

実験手法

X-RAY DIFFRACTION (1.9 Å)