1YT9

HIV Protease with oximinoarylsulfonamide bound

Summary for 1YT9

• Entry DOI: 10.2210/pdb1yt9/pdb
• Related: 1MUI
• Descriptor: Pol polyprotein, (S)-N-((2S,3R)-3-HYDROXY-4-(4-((E)-(HYDROXYIMINO)METHYL)-N-ISOBUTYLPHENYLSULFONAMIDO)-1-PHENYLBUTAN-2-YL)-3-METHYL-2-(3 -((2-METHYLTHIAZOL-4-YL)METHYL)-2-OXOIMIDAZOLIDIN-1-YL)BUTANAMIDE (2 entities in total)
• Functional Keywords: hiv protease, oximinoarylsulfonamides, hydrolase
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 2
• Total formula weight: 22306.41

Authors

Yeung, C.M.,Klein, L.L.,Flentge, C.A.,Randolph, J.T.,Zhao, C.,Sun, M.,Dekhtyar, T.,Stoll, V.S.,Kempf, D.J. (deposition date: 2005-02-10, release date: 2005-04-12, Last modification date: 2024-02-14)

• Primary citation: Yeung, C.M.,Klein, L.L.,Flentge, C.A.,Randolph, J.T.,Zhao, C.,Sun, M.,Dekhtyar, T.,Stoll, V.S.,Kempf, D.J.; Oximinoarylsulfonamides as potent HIV protease inhibitors.; Bioorg.Med.Chem.Lett., 15:2275-2278, 2005; PubMed: 15837308; DOI: 10.1016/j.bmcl.2005.03.008

Experimental method

X-RAY DIFFRACTION (3 Å)