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2A3U

Crystal structure of sulbactam bound to E166A variant of SHV-1 beta-lactamase

Summary for 2A3U
Entry DOI10.2210/pdb2a3u/pdb
Related1rcj 2a49
DescriptorBeta-lactamase SHV-1, TRANS-ENAMINE INTERMEDIATE OF SULBACTAM, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, ... (5 entities in total)
Functional Keywordsbeta-lactamase, beta-lactam hydrolase, penicillinase, detergent binding, inhibitor design, covalent intermediate, hydrolase
Biological sourceKlebsiella pneumoniae
Total number of polymer chains1
Total formula weight30910.49
Authors
Padayatti, P.S.,Helfand, M.S.,Totir, M.A.,Carey, M.P.,Carey, P.R.,Bonomo, R.A.,van den Akker, F. (deposition date: 2005-06-27, release date: 2005-08-02, Last modification date: 2021-10-20)
Primary citationPadayatti, P.S.,Helfand, M.S.,Totir, M.A.,Carey, M.P.,Carey, P.R.,Bonomo, R.A.,van den Akker, F.
High Resolution Crystal Structures of the trans-Enamine Intermediates Formed by Sulbactam and Clavulanic Acid and E166A SHV-1 {beta}-Lactamase.
J.Biol.Chem., 280:34900-34907, 2005
Cited by
PubMed: 16055923
DOI: 10.1074/jbc.M505333200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.34 Å)
Structure validation

217705

數據於2024-03-27公開中

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