2A0M

Arginase superfamily protein from Trypanosoma cruzi

Summary for 2A0M

• Entry DOI: 10.2210/pdb2a0m/pdb
• Descriptor: ARGINASE SUPERFAMILY PROTEIN, CHLORIDE ION (3 entities in total)
• Functional Keywords: structural genomics, arginase, psi, protein structure initiative, structural genomics of pathogenic protozoa consortium, sgpp, hydrolase
• Biological source: Trypanosoma cruzi
• Total number of polymer chains: 1
• Total formula weight: 34713.73

Authors

Arakaki, T.L.,Merritt, E.A.,Structural Genomics of Pathogenic Protozoa Consortium (SGPP) (deposition date: 2005-06-16, release date: 2005-07-05, Last modification date: 2024-04-03)

Primary citation

Fan, E.,Baker, D.,Fields, S.,Gelb, M.H.,Buckner, F.S.,Van Voorhis, W.C.,Phizicky, E.,Dumont, M.,Mehlin, C.,Grayhack, E.,Sullivan, M.,Verlinde, C.,Detitta, G.,Meldrum, D.R.,Merritt, E.A.,Earnest, T.,Soltis, M.,Zucker, F.,Myler, P.J.,Schoenfeld, L.,Kim, D.,Worthey, L.,Lacount, D.,Vignali, M.,Li, J.,Mondal, S.,Massey, A.,Carroll, B.,Gulde, S.,Luft, J.,Desoto, L.,Holl, M.,Caruthers, J.,Bosch, J.,Robien, M.,Arakaki, T.,Holmes, M.,Le Trong, I.,Hol, W.G.
Structural genomics of pathogenic protozoa: an overview.
Methods Mol.Biol., 426:497-513, 2008

PubMed Abstract: The Structural Genomics of Pathogenic Protozoa (SGPP) Consortium aimed to determine crystal structures of proteins from trypanosomatid and malaria parasites in a high throughput manner. The pipeline of target selection, protein production, crystallization, and structure determination, is sketched. Special emphasis is given to a number of technology developments including domain prediction, the use of "co-crystallants," and capillary crystallization. "Fragment cocktail crystallography" for medical structural genomics is also described.

PubMed: 18542886
DOI: 10.1007/978-1-60327-058-8_33

Experimental method

X-RAY DIFFRACTION (1.603 Å)