2XP3

DISCOVERY OF CELL-ACTIVE PHENYL-IMIDAZOLE PIN1 INHIBITORS BY STRUCTURE-GUIDED FRAGMENT EVOLUTION

Summary for 2XP3

Entry DOI	10.2210/pdb2xp3/pdb
Related	1F8A 1I6C 1I8G 1I8H 1NMV 1NMW 1PIN 1ZCN 2F21 2XP4 2XP5 2XP6 2XP7 2XP8 2XP9 2XPA 2XPB
Descriptor	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE NIMA-INTERACTING 1, DODECAETHYLENE GLYCOL, 5-(2-METHOXYPHENYL)-2-FUROIC ACID, ... (4 entities in total)
Functional Keywords	isomerase, proline directed kinase, cell cycle, oncogenic transformation
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	19289.38
Authors	Potter, A.,Oldfield, V.,Nunns, C.,Fromont, C.,Ray, S.,Northfield, C.J.,Bryant, C.J.,Scrace, S.F.,Robinson, D.,Matossova, N.,Baker, L.,Dokurno, P.,Surgenor, A.E.,Davis, B.E.,Richardson, C.M.,Murray, J.B.,Moore, J.D. (deposition date: 2010-08-25, release date: 2011-01-12, Last modification date: 2023-12-20)
Primary citation	Potter, A.,Oldfield, V.,Nunns, C.,Fromont, C.,Ray, S.,Northfield, C.J.,Bryant, C.J.,Scrace, S.F.,Robinson, D.,Matossova, N.,Baker, L.,Dokurno, P.,Surgenor, A.E.,Davis, B.,Richardson, C.M.,Murray, J.B.,Moore, J.D. Discovery of Cell-Active Phenyl-Imidazole Pin1 Inhibitors by Structure-Guided Fragment Evolution. Bioorg.Med.Chem.Lett., 20:6483-, 2010 Cited by PubMed: 20932746 DOI: 10.1016/J.BMCL.2010.09.063 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation