2WFO
Crystal structure of Machupo virus envelope glycoprotein GP1
Summary for 2WFO
| Entry DOI | 10.2210/pdb2wfo/pdb |
| Descriptor | GLYCOPROTEIN 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
| Functional Keywords | glycoprotein, arenavirus, new world arenavirus, hemorrhagic fever virus, envelope protein, machupo, junin, guanarito, sabia, chapare, virion, macv, gp1, viral attachment, transferrin receptor, viral protein |
| Biological source | Machupo virus |
| Total number of polymer chains | 1 |
| Total formula weight | 22138.96 |
| Authors | Bowden, T.A.,Crispin, M.,Graham, S.C.,Harvey, D.J.,Grimes, J.M.,Jones, E.Y.,Stuart, D.I. (deposition date: 2009-04-09, release date: 2009-06-16, Last modification date: 2024-11-13) |
| Primary citation | Bowden, T.A.,Crispin, M.,Graham, S.C.,Harvey, D.J.,Grimes, J.M.,Jones, E.Y.,Stuart, D.I. Unusual Molecular Architecture of the Machupo Virus Attachment Glycoprotein. J.Virol., 83:8259-, 2009 Cited by PubMed Abstract: New World arenaviruses, which cause severe hemorrhagic fever, rely upon their envelope glycoproteins for attachment and fusion into their host cell. Here we present the crystal structure of the Machupo virus GP1 attachment glycoprotein, which is responsible for high-affinity binding at the cell surface to the transferrin receptor. This first structure of an arenavirus glycoprotein shows that GP1 consists of a novel alpha/beta fold. This provides a blueprint of the New World arenavirus attachment glycoproteins and reveals a new architecture of viral attachment, using a protein fold of unknown origins. PubMed: 19494008DOI: 10.1128/JVI.00761-09 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.73 Å) |
Structure validation
Download full validation report
