2VAQ

STRUCTURE OF STRICTOSIDINE SYNTHASE IN COMPLEX WITH INHIBITOR

Summary for 2VAQ

• Entry DOI: 10.2210/pdb2vaq/pdb
• Related: 2FP8 2FP9 2FPB 2FPC 2V91
• Descriptor: STRICTOSIDINE SYNTHASE, (2S,3R,4S)-methyl 4-(2-(2-(1H-indol-3-yl)ethylamino)ethyl)-2-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)-3-vinyl-3,4-dihydro-2H-pyran-5-carboxylate (3 entities in total)
• Functional Keywords: alkaloid metabolism, glycoprotein, lyase, six bladed beta propeller fold, str1, synthase, vacuole
• Biological source: RAUVOLFIA SERPENTINA (SERPENTWOOD)
• Total number of polymer chains: 2
• Total formula weight: 72597.04

Authors

Maresh, J.,Giddings, L.A.,Friedrich, A.,Loris, E.A.,Panjikar, S.,Trout, B.L.,Stoeckigt, J.,Peters, B.,O'Connor, S.E. (deposition date: 2007-09-04, release date: 2008-09-16, Last modification date: 2023-12-13)

• Primary citation: Maresh, J.J.,Giddings, L.A.,Friedrich, A.,Loris, E.A.,Panjikar, S.,Trout, B.L.,Stockigt, J.,Peters, B.,O'Connor, S.E.; Strictosidine synthase: mechanism of a Pictet-Spengler catalyzing enzyme.; J. Am. Chem. Soc., 130:710-723, 2008; PubMed: 18081287; DOI: 10.1021/ja077190z

Experimental method

X-RAY DIFFRACTION (3.01 Å)