2SEM

SEM5 SH3 DOMAIN COMPLEXED WITH PEPTOID INHIBITOR

Summary for 2SEM

Entry DOI	10.2210/pdb2sem/pdb
Related PRD ID	PRD_000245
Descriptor	PROTEIN (SEX MUSCLE ABNORMAL PROTEIN 5), PROTEIN (SH3 PEPTOID INHIBITOR) (3 entities in total)
Functional Keywords	sh3 domain, inhibitors, peptoids, protein-protein recognition, proline-rich motifs, signal transduction, signaling protein, signaling protein-inhibitor complex, signaling protein/inhibitor
Biological source	Caenorhabditis elegans More
Total number of polymer chains	4
Total formula weight	15891.70
Authors	Nguyen, J.T.,Turck, C.W.,Cohen, F.E.,Zuckermann, R.N.,Lim, W.A. (deposition date: 1998-11-02, release date: 1999-01-06, Last modification date: 2023-11-15)
Primary citation	Nguyen, J.T.,Turck, C.W.,Cohen, F.E.,Zuckermann, R.N.,Lim, W.A. Exploiting the basis of proline recognition by SH3 and WW domains: design of N-substituted inhibitors. Science, 282:2088-2092, 1998 Cited by PubMed: 9851931 DOI: 10.1126/science.282.5396.2088 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation