2RG5
Phenylalanine pyrrolotriazine p38 alpha map kinase inhibitor compound 11B
Summary for 2RG5
Entry DOI | 10.2210/pdb2rg5/pdb |
Descriptor | Mitogen-activated protein kinase 14, N-ethyl-4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide (3 entities in total) |
Functional Keywords | serine/threonine-protein kinase, kinase, transferase, p38 map kinase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (By similarity): Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 42487.42 |
Authors | Sack, J.S. (deposition date: 2007-10-02, release date: 2008-01-15, Last modification date: 2024-02-21) |
Primary citation | Hynes, J.,Dyckman, A.J.,Lin, S.,Wrobleski, S.T.,Wu, H.,Gillooly, K.M.,Kanner, S.B.,Lonial, H.,Loo, D.,McIntyre, K.W.,Pitt, S.,Shen, D.R.,Shuster, D.J.,Yang, X.,Zhang, R.,Behnia, K.,Zhang, H.,Marathe, P.H.,Doweyko, A.M.,Tokarski, J.S.,Sack, J.S.,Pokross, M.,Kiefer, S.E.,Newitt, J.A.,Barrish, J.C.,Dodd, J.,Schieven, G.L.,Leftheris, K. Design, Synthesis, and Anti-inflammatory Properties of Orally Active 4-(Phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha Mitogen-Activated Protein Kinase Inhibitors J.Med.Chem., 51:4-16, 2008 Cited by PubMed: 18072718DOI: 10.1021/jm7009414 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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