2R3P
Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor
Summary for 2R3P
Entry DOI | 10.2210/pdb2r3p/pdb |
Related | 2R3F 2R3G 2R3H 2R3I 2R3J 2R3K 2R3L 2R3M 2R3N 2R3O 2R3Q 2R3R |
Descriptor | Cell division protein kinase 2, 5-(2,3-dichlorophenyl)-N-(pyridin-4-ylmethyl)-3-thiocyanatopyrazolo[1,5-a]pyrimidin-7-amine (3 entities in total) |
Functional Keywords | serine/threonine-protein kinase, cell cycle, inhibition, cyclin-dependent kinase, cancer, atp-binding, cell division, mitosis, nucleotide-binding, phosphorylation, polymorphism, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 34461.84 |
Authors | Fischmann, T.O.,Hruza, A.W.,Madison, V.M.,Duca, J.S. (deposition date: 2007-08-29, release date: 2008-01-22, Last modification date: 2024-10-16) |
Primary citation | Fischmann, T.O.,Hruza, A.,Duca, J.S.,Ramanathan, L.,Mayhood, T.,Windsor, W.T.,Le, H.V.,Guzi, T.J.,Dwyer, M.P.,Paruch, K.,Doll, R.J.,Lees, E.,Parry, D.,Seghezzi, W.,Madison, V. Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89:372-379, 2008 Cited by PubMed: 17937404DOI: 10.1002/bip.20868 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.66 Å) |
Structure validation
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