2QZL

Crystal Structure of human Beta Secretase complexed with IXS

Summary for 2QZL

Entry DOI	10.2210/pdb2qzl/pdb
Related	2QZK
Descriptor	Beta-secretase 1, N-[(1S)-1-benzyl-2-{[(1S)-2-(isobutylamino)-1-methyl-2-oxoethyl]amino}ethyl]-N'-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]isophthalamide (3 entities in total)
Functional Keywords	aspartyl protease, bace, alternative splicing, glycoprotein, hydrolase, membrane, transmembrane, zymogen
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: P56817
Total number of polymer chains	1
Total formula weight	46453.30
Authors	Munshi, S. (deposition date: 2007-08-16, release date: 2008-04-22, Last modification date: 2023-08-30)
Primary citation	Coburn, C.A.,Stachel, S.J.,Jones, K.G.,Steele, T.G.,Rush, D.M.,DiMuzio, J.,Pietrak, B.L.,Lai, M.T.,Huang, Q.,Lineberger, J.,Jin, L.,Munshi, S.,Holloway, K.M.,Espeseth, A.,Simon, A.,Hazuda, D.,Graham, S.L.,Vacca, J.P. BACE-1 inhibition by a series of psi[CH2NH] reduced amide isosteres Bioorg.Med.Chem.Lett., 16:3635-3638, 2006 Cited by PubMed: 16690314 DOI: 10.1016/j.bmcl.2006.04.076 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation