2QWI
THE X-RAY STRUCTURE OF A COMPLEX OF N-ACETYL-4-GUANIDINO-6-METHYL(PROPYL)CARBOXAMIDE-4,5-DIHYDRO-2H-PYRAN-2-CARBOXYLIC ACID AND WILDTYPE TERN N9 INFLUENZA VIRUS NEURAMINIDASE
Summary for 2QWI
Entry DOI | 10.2210/pdb2qwi/pdb |
Descriptor | NEURAMINIDASE, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose, ... (7 entities in total) |
Functional Keywords | neuraminidase, influenza protein, drug resistant variant, sialic acid analogues, dana anologues, glycosylated protein, hydrolase, carboxamide derivatives |
Biological source | Influenza A virus |
Cellular location | Virion membrane (By similarity): P03472 |
Total number of polymer chains | 1 |
Total formula weight | 45800.75 |
Authors | Varghese, J.N. (deposition date: 1998-04-07, release date: 1998-11-11, Last modification date: 2024-04-03) |
Primary citation | Varghese, J.N.,Smith, P.W.,Sollis, S.L.,Blick, T.J.,Sahasrabudhe, A.,McKimm-Breschkin, J.L.,Colman, P.M. Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase. Structure, 6:735-746, 1998 Cited by PubMed: 9655825DOI: 10.1016/S0969-2126(98)00075-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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