2QFO
HSP90 complexed with A143571 and A516383
Summary for 2QFO
Entry DOI | 10.2210/pdb2qfo/pdb |
Descriptor | Heat shock protein HSP 90-alpha, 4-METHYL-6-(TRIFLUOROMETHYL)PYRIMIDIN-2-AMINE, (3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-one, ... (4 entities in total) |
Functional Keywords | protein-inhibitor complex, atp-binding, chaperone, nucleotide-binding, phosphoprotein, stress response |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P07900 |
Total number of polymer chains | 2 |
Total formula weight | 46634.78 |
Authors | Park, C.H. (deposition date: 2007-06-27, release date: 2008-07-01, Last modification date: 2023-08-30) |
Primary citation | Huth, J.R.,Park, C.,Petros, A.M.,Kunzer, A.R.,Wendt, M.D.,Wang, X.,Lynch, C.L.,Mack, J.C.,Swift, K.M.,Judge, R.A.,Chen, J.,Richardson, P.L.,Jin, S.,Tahir, S.K.,Matayoshi, E.D.,Dorwin, S.A.,Ladror, U.S.,Severin, J.M.,Walter, K.A.,Bartley, D.M.,Fesik, S.W.,Elmore, S.W.,Hajduk, P.J. Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies. CHEM.BIOL.DRUG DES., 70:1-12, 2007 Cited by PubMed: 17630989DOI: 10.1111/j.1747-0285.2007.00535.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.68 Å) |
Structure validation
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