2QD9

P38 Alpha Map Kinase inhibitor based on heterobicyclic scaffolds

Summary for 2QD9

• Entry DOI: 10.2210/pdb2qd9/pdb
• Descriptor: Mitogen-activated protein kinase 14, 1-[5-[[3-[2,4-bis(fluoranyl)phenyl]-6,8-dihydro-5~{H}-imidazo[1,5-a]pyrazin-7-yl]carbonyl]-6-methoxy-1~{H}-pyrrolo[2,3-b]pyridin-3-yl]-2-[(3~{R})-3-oxidanylpyrrolidin-1-yl]ethane-1,2-dione (3 entities in total)
• Functional Keywords: serine/threonine-protein kinase, kinase, transferase, p38 map kinase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 42655.52

Authors

Sack, J.S. (deposition date: 2007-06-20, release date: 2007-08-21, Last modification date: 2024-02-21)

• Primary citation: Murali Dhar, T.G.,Wrobleski, S.T.,Lin, S.,Furch, J.A.,Nirschl, D.S.,Fan, Y.,Todderud, G.,Pitt, S.,Doweyko, A.M.,Sack, J.S.,Mathur, A.,McKinnon, M.,Barrish, J.C.,Dodd, J.H.,Schieven, G.L.,Leftheris, K.; Synthesis and SAR of p38alpha MAP kinase inhibitors based on heterobicyclic scaffolds.; Bioorg.Med.Chem.Lett., 17:5019-5024, 2007; PubMed: 17664068; DOI: 10.1016/j.bmcl.2007.07.029

Experimental method

X-RAY DIFFRACTION (1.7 Å)