2Q7W
Structural Studies Reveals the Inactivation of E. coli L-aspartate aminotransferase (S)-4,5-amino-dihydro-2-thiophenecarboxylic acid (SADTA) via two mechanisms at pH 6.0
Summary for 2Q7W
Entry DOI | 10.2210/pdb2q7w/pdb |
Descriptor | Aspartate aminotransferase, SULFATE ION, 4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]THIOPHENE-2-CARBOXYLIC ACID, ... (6 entities in total) |
Functional Keywords | mechanism-based inhibitor, plp, sadta, ph dependence, transferase |
Biological source | Escherichia coli |
Cellular location | Cytoplasm: P00509 |
Total number of polymer chains | 1 |
Total formula weight | 45475.91 |
Authors | Liu, D.,Pozharski, E.,Lepore, B.,Fu, M.,Silverman, R.B.,Petsko, G.A.,Ringe, D. (deposition date: 2007-06-07, release date: 2007-09-04, Last modification date: 2023-08-30) |
Primary citation | Liu, D.,Pozharski, E.,Lepore, B.W.,Fu, M.,Silverman, R.B.,Petsko, G.A.,Ringe, D. Inactivation of Escherichia coli l-Aspartate Aminotransferase by (S)-4-Amino-4,5-dihydro-2-thiophenecarboxylic Acid Reveals "A Tale of Two Mechanisms". Biochemistry, 46:10517-10527, 2007 Cited by PubMed: 17713924DOI: 10.1021/bi700663n PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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