2POW

The crystal structure of the human carbonic anhydrase II in complex with 4-amino-6-trifluoromethyl-benzene-1,3-disulfonamide

Summary for 2POW

Entry DOI	10.2210/pdb2pow/pdb
Related	2POU 2POV
Descriptor	Carbonic anhydrase 2, ZINC ION, 4-AMINO-6-(TRIFLUOROMETHYL)BENZENE-1,3-DISULFONAMIDE, ... (4 entities in total)
Functional Keywords	carbonic anhydrase ii, protein-inhibitor complexes, lyase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P00918
Total number of polymer chains	1
Total formula weight	29673.75
Authors	Alterio, V.,De Simone, G. (deposition date: 2007-04-27, release date: 2007-07-24, Last modification date: 2023-08-30)
Primary citation	Alterio, V.,De Simone, G.,Monti, S.M.,Scozzafava, A.,Supuran, C.T. Carbonic anhydrase inhibitors: Inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides-Solution and crystallographic studies. Bioorg.Med.Chem.Lett., 17:4201-4207, 2007 Cited by PubMed: 17540563 DOI: 10.1016/j.bmcl.2007.05.045 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation