2PK6
Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I) in Complex with KNI-10033
Summary for 2PK6
Entry DOI | 10.2210/pdb2pk6/pdb |
Related PRD ID | PRD_000585 |
Descriptor | Protease, (4R)-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-3-[(2S,3S)-2-hydroxy-3-({N-[(isoquinolin-5-yloxy)acetyl]-S-methyl- L-cysteinyl}amino)-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide, GLYCEROL, ... (4 entities in total) |
Functional Keywords | protease complex, viral protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367 |
Total number of polymer chains | 2 |
Total formula weight | 22473.66 |
Authors | Armstrong, A.A.,Lafont, V.,Kiso, Y.,Freire, E.,Amzel, L.M. (deposition date: 2007-04-17, release date: 2007-05-08, Last modification date: 2023-08-30) |
Primary citation | Lafont, V.,Armstrong, A.A.,Ohtaka, H.,Kiso, Y.,Mario Amzel, L.,Freire, E. Compensating enthalpic and entropic changes hinder binding affinity optimization. Chem.Biol.Drug Des., 69:413-422, 2007 Cited by PubMed: 17581235DOI: 10.1111/j.1747-0285.2007.00519.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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