2OSM

Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study

Summary for 2OSM

• Entry DOI: 10.2210/pdb2osm/pdb
• Related: 2OSF
• Descriptor: Carbonic anhydrase 2, ZINC ION, 2-MERCAPTOPHENOL, ... (4 entities in total)
• Functional Keywords: human carbonic anhydrase ii, 2-hydroxythiophenol, lyase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P00918
• Total number of polymer chains: 1
• Total formula weight: 29349.45

Authors

Albert, A.B.,Caroli, G.,Govindasamy, L.,Agbandje-Mckenna, M.,McKenna, R.,Tripp, B.C. (deposition date: 2007-02-06, release date: 2008-02-12, Last modification date: 2023-08-30)

• Primary citation: Barrese, A.A.,Genis, C.,Fisher, S.Z.,Orwenyo, J.N.,Kumara, M.T.,Dutta, S.K.,Phillips, E.,Kiddle, J.J.,Tu, C.,Silverman, D.N.,Govindasamy, L.,Agbandje-McKenna, M.,McKenna, R.,Tripp, B.C.; Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study.; Biochemistry, 47:3174-3184, 2008; PubMed: 18266323; DOI: 10.1021/bi702385k

Experimental method

X-RAY DIFFRACTION (1.6 Å)