2ODD

Solution structure of the MYND domain from AML1-ETO complexed with SMRT, a corepressor

Summary for 2ODD

• Entry DOI: 10.2210/pdb2odd/pdb
• Related: 2OD1
• Descriptor: SMRT, Protein CBFA2T1, ZINC ION (3 entities in total)
• Functional Keywords: mynd zinc finger, cross-braced topology, poly-proline, proline-tryptophan interaction, metal binding protein
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus (Potential): Q06455
• Total number of polymer chains: 2
• Total formula weight: 9105.61

Authors

Liu, Y.Z.,Chen, W.,Gaudet, J.,Cheney, M.D.,Roudaia, L.,Cierpicki, T.,Klet, R.C.,Hartman, K.,Laue, T.M.,Speck, N.A.,Bushweller, J.H. (deposition date: 2006-12-22, release date: 2007-06-19, Last modification date: 2023-12-27)

• Primary citation: Liu, Y.,Chen, W.,Gaudet, J.,Cheney, M.D.,Roudaia, L.,Cierpicki, T.,Klet, R.C.,Hartman, K.,Laue, T.M.,Speck, N.A.,Bushweller, J.H.; Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity.; Cancer Cell, 11:483-497, 2007; PubMed: 17560331; DOI: 10.1016/j.ccr.2007.04.010

Experimental method

SOLUTION NMR