2O4Z

Crystal structure of the Carbonic Anhydrase II complexed with hydroxysulfamide inhibitor

Summary for 2O4Z

Entry DOI	10.2210/pdb2o4z/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, MERCURY (II) ION, ... (5 entities in total)
Functional Keywords	carbonic anhydrase, inhibitors, lyase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	29667.17
Authors	Temperini, C.,Winum, J.Y.,Montero, J.L.,Scozzafava, a.,Supuran, c.t. (deposition date: 2006-12-05, release date: 2007-05-15, Last modification date: 2023-08-30)
Primary citation	Temperini, C.,Winum, J.Y.,Montero, J.L.,Scozzafava, A.,Supuran, C.T. Carbonic anhydrase inhibitors: The X-ray crystal structure of the adduct of N-hydroxysulfamide with isozyme II explains why this new zinc binding function is effective in the design of potent inhibitors. Bioorg.Med.Chem.Lett., 17:2795-2801, 2007 Cited by PubMed: 17346964 DOI: 10.1016/j.bmcl.2007.02.068 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation