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2NZ8

N-terminal DHPH cassette of Trio in complex with nucleotide-free Rac1

Summary for 2NZ8
Entry DOI10.2210/pdb2nz8/pdb
Descriptorras-related C3 botulinum toxin substrate 1 isoform Rac1, triple functional domain protein (3 entities in total)
Functional Keywordstrio; rac1; dbl-family gef; rho-family gtpase; dh/ph cassette, signaling protein, cell cycle
Biological sourceHomo sapiens (human)
More
Cellular locationCell membrane ; Lipid-anchor ; Cytoplasmic side : P63000
Cytoplasm : O75962
Total number of polymer chains2
Total formula weight56272.72
Authors
Chhatriwala, M.K.,Betts, L.,Worthylake, D.K.,Sondek, J. (deposition date: 2006-11-22, release date: 2007-04-10, Last modification date: 2023-08-30)
Primary citationChhatriwala, M.K.,Betts, L.,Worthylake, D.K.,Sondek, J.
The DH and PH Domains of Trio Coordinately Engage Rho GTPases for their Efficient Activation
J.Mol.Biol., 368:1307-1320, 2007
Cited by
PubMed: 17391702
DOI: 10.1016/j.jmb.2007.02.060
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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