2MPT

WW3 domain of Nedd4L in complex with its HECT domain PY motif

Summary for 2MPT

• Entry DOI: 10.2210/pdb2mpt/pdb
• NMR Information: BMRB: 25000
• Descriptor: E3 ubiquitin-protein ligase NEDD4-like (2 entities in total)
• Functional Keywords: ww, nedd4l, nedd4.2, hect, py, ww3, auto-ubiquitination, proteasomal degradation, ubiquitin ligase, ligase
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm : Q96PU5 Q96PU5
• Total number of polymer chains: 2
• Total formula weight: 7272.28

Authors

Escobedo, A.,Macias, M.J.,Gomes, T.,Aragon, E.,Martin-Malpartida, P.,Ruiz, L. (deposition date: 2014-06-02, release date: 2014-10-22)

• Primary citation: Escobedo, A.,Gomes, T.,Aragon, E.,Martin-Malpartida, P.,Ruiz, L.,Macias, M.J.; Structural Basis of the Activation and Degradation Mechanisms of the E3 Ubiquitin Ligase Nedd4L.; Structure, 22:1446-1457, 2014; PubMed: 25295397; DOI: 10.1016/j.str.2014.08.016

Experimental method

SOLUTION NMR