2MC1
Solution structure of the Vav1 SH2 domain complexed with a Syk-derived singly phosphorylated peptide
Summary for 2MC1
| Entry DOI | 10.2210/pdb2mc1/pdb |
| NMR Information | BMRB: 19423 |
| Descriptor | Proto-oncogene vav, Tyrosine-protein kinase SYK (2 entities in total) |
| Functional Keywords | syk kinase, tyrosine kinase, phosphorylated peptide, phosphotyrosine binding domain, b cell signaling protein, signaling protein-protein binding complex, signaling protein/protein binding |
| Biological source | Homo sapiens (human) More |
| Cellular location | Cell membrane (Probable): P48025 |
| Total number of polymer chains | 2 |
| Total formula weight | 13929.62 |
| Authors | Chen, C.,Piraner, D.,Gorenstein, N.M.,Geahlen, R.L.,Post, C.B. (deposition date: 2013-08-13, release date: 2013-08-28, Last modification date: 2023-06-14) |
| Primary citation | Chen, C.H.,Piraner, D.,Gorenstein, N.M.,Geahlen, R.L.,Beth Post, C. Differential recognition of syk-binding sites by each of the two phosphotyrosine-binding pockets of the Vav SH2 domain. Biopolymers, 99:897-907, 2013 Cited by PubMed: 23955592DOI: 10.1002/bip.22371 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
Download full validation report
