2M2M

Structure of [L-HisB24] insulin analogue at pH 1.9

Summary for 2M2M
Related2M2N 2M2O 2M2P
NMR InformationBMRB: 18921
DescriptorInsulin A chain, Insulin B chain (2 entities in total)
Functional Keywordsinsulin, hormone
Biological sourceHomo sapiens (human)
More
Cellular locationSecreted: P01308 P01308
Total number of polymer chains2
Total formula weight5808.62
Authors
Zakova, L.,Veverka, V.,Jiracek, J. (deposition date: 2012-12-28, release date: 2013-03-06, Last modification date: 2013-06-05)
Primary citationBrzozowski, A.M.,Jiracek, J.,Kletvikova, E.,Lepsik, M.,Turkenburg, J.P.,Veverka, V.,Watson, C.J.
Structural integrity of the B24 site in human insulin is important for hormone functionality.
J.Biol.Chem., 288:10230-10240, 2013
PubMed: 23447530
DOI: 110.1074/jbc.M112.448050
PDB entries with the same primary citation
Experimental method
SOLUTION NMR
Structure validation
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PDB entries from 2021-06-16