2M0X

Solution structure of U14Ub1, an engineered ubiquitin variant with increased affinity for USP14

Summary for 2M0X

Entry DOI	10.2210/pdb2m0x/pdb
NMR Information	BMRB: 18831
Descriptor	engineered ubiquitin variant (1 entity in total)
Functional Keywords	de novo protein
Biological source	Homo sapiens
Total number of polymer chains	1
Total formula weight	8709.90
Authors	Phillips, A.H.,Fairbrother, W.J.,Corn, J.E. (deposition date: 2012-11-08, release date: 2013-06-26, Last modification date: 2023-06-14)
Primary citation	Phillips, A.H.,Zhang, Y.,Cunningham, C.N.,Zhou, L.,Forrest, W.F.,Liu, P.S.,Steffek, M.,Lee, J.,Tam, C.,Helgason, E.,Murray, J.M.,Kirkpatrick, D.S.,Fairbrother, W.J.,Corn, J.E. Conformational dynamics control ubiquitin-deubiquitinase interactions and influence in vivo signaling. Proc.Natl.Acad.Sci.USA, 110:11379-11384, 2013 Cited by PubMed: 23801757 DOI: 10.1073/pnas.1302407110 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation