2LY4

HMGB1-facilitated p53 DNA binding occurs via HMG-box/p53 transactivation domain interaction and is regulated by the acidic tail

Summary for 2LY4

Entry DOI	10.2210/pdb2ly4/pdb
NMR Information	BMRB: 18709
Descriptor	High mobility group protein B1, Cellular tumor antigen p53 (2 entities in total)
Functional Keywords	hmg, p53, tad, nuclear protein-antitumour protein complex, nuclear protein/antitumour protein
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: P09429 Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
Total number of polymer chains	2
Total formula weight	19686.19
Authors	Rowell, J.P.,Simpson, K.L.,Stott, K.,Watson, M.,Thomas, J.O. (deposition date: 2012-09-12, release date: 2012-10-31, Last modification date: 2012-12-26)
Primary citation	Rowell, J.P.,Simpson, K.L.,Stott, K.,Watson, M.,Thomas, J.O. HMGB1-Facilitated p53 DNA Binding Occurs via HMG-Box/p53 Transactivation Domain Interaction, Regulated by the Acidic Tail. Structure, 20:2014-2024, 2012 Cited by PubMed: 23063560 DOI: 10.1016/j.str.2012.09.004 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation