2LVG

NMR structure of HCV Non-structural protein AB, NS4B(1-40)

Summary for 2LVG

• Entry DOI: 10.2210/pdb2lvg/pdb
• Related: 2jxf
• NMR Information: BMRB: 18568
• Descriptor: Non-structural protein 4B (1 entity in total)
• Functional Keywords: membrane protein
• Biological source: Hepatitis C virus JFH-1 (HCV)
• Cellular location: Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : Q99IB8
• Total number of polymer chains: 1
• Total formula weight: 4385.05

Authors

Montserret, R.,Penin, F. (deposition date: 2012-07-05, release date: 2013-06-19, Last modification date: 2023-06-14)

• Primary citation: Gouttenoire, J.,Montserret, R.,Paul, D.,Castillo, R.,Meister, S.,Bartenschlager, R.,Penin, F.,Moradpour, D.; Aminoterminal Amphipathic alpha-Helix AH1 of Hepatitis C Virus Nonstructural Protein 4B Possesses a Dual Role in RNA Replication and Virus Production.; Plos Pathog., 10:e1004501-e1004501, 2014; PubMed: 25392992; DOI: 10.1371/journal.ppat.1004501

Experimental method

SOLUTION NMR