2LP1

The solution NMR structure of the transmembrane C-terminal domain of the amyloid precursor protein (C99)

Summary for 2LP1

• Entry DOI: 10.2210/pdb2lp1/pdb
• NMR Information: BMRB: 15775
• Descriptor: C99 (1 entity in total)
• Functional Keywords: amyloid precursor protein c-terminal fragment, alzheimer's disease, membrane protein, amyloid-beta precursor, transmembrane protein
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein: P05067
• Total number of polymer chains: 1
• Total formula weight: 13801.77

Authors

Barrett, P.J.,Song, Y.,Van Horn, W.D.,Hustedt, E.J.,Schafer, J.M.,Hadziselimovic, A.,Beel, A.J.,Sanders, C.R. (deposition date: 2012-01-30, release date: 2012-06-06, Last modification date: 2012-06-20)

• Primary citation: Barrett, P.J.,Song, Y.,Van Horn, W.D.,Hustedt, E.J.,Schafer, J.M.,Hadziselimovic, A.,Beel, A.J.,Sanders, C.R.; The amyloid precursor protein has a flexible transmembrane domain and binds cholesterol.; Science, 336:1168-1171, 2012; PubMed: 22654059; DOI: 10.1126/science.1219988

Experimental method

SOLUTION NMR