2LB2

Structure of the second domain of human Nedd4L in complex with a phosphorylated pTPY motif derived from human Smad3

Summary for 2LB2

• Entry DOI: 10.2210/pdb2lb2/pdb
• Related: 2LAW 2LAX 2LAY 2LAZ 2LB0 2LB1 2LB3
• NMR Information: BMRB: 17544
• Descriptor: E3 ubiquitin-protein ligase NEDD4-like, Mothers against decapentaplegic homolog 3 (2 entities in total)
• Functional Keywords: nedd4l, smad, cdk, signal transduction, signaling protein-transcription complex, signaling protein/transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: Q96PU5 P84022
• Total number of polymer chains: 2
• Total formula weight: 5525.95

Authors

Macias, M.J.,Aragon, E.,Goerner, N.,Zaromytidou, A.,Xi, Q.,Escobedo, A.,Massague, J. (deposition date: 2011-03-22, release date: 2011-07-06, Last modification date: 2011-07-13)

• Primary citation: Aragon, E.,Goerner, N.,Zaromytidou, A.I.,Xi, Q.,Escobedo, A.,Massague, J.,Macias, M.J.; A Smad action turnover switch operated by WW domain readers of a phosphoserine code.; Genes Dev., 25:1275-1288, 2011; PubMed: 21685363; DOI: 10.1101/gad.2060811

Experimental method

SOLUTION NMR