2KYS
NMR Structure of the SARS Coronavirus Nonstructural Protein Nsp7 in Solution at pH 6.5
Summary for 2KYS
| Entry DOI | 10.2210/pdb2kys/pdb |
| NMR Information | BMRB: 16981 |
| Descriptor | Non-structural protein 7 (1 entity in total) |
| Functional Keywords | severe acute respiratory syndrome (sars), coronavirus, nsp7, conformational polymorphism, structural genomics, psi-2, protein structure initiative, joint center for structural genomics, jcsg, viral protein |
| Biological source | SARS coronavirus |
| Total number of polymer chains | 1 |
| Total formula weight | 9472.02 |
| Authors | Johnson, M.A.,Jaudzems, K.,Wilson, I.A.,Wuthrich, K.,Joint Center for Structural Genomics (JCSG) (deposition date: 2010-06-07, release date: 2010-06-16, Last modification date: 2024-05-15) |
| Primary citation | Johnson, M.A.,Jaudzems, K.,Wuthrich, K. NMR Structure of the SARS-CoV Nonstructural Protein 7 in Solution at pH 6.5. J.Mol.Biol., 402:619-628, 2010 Cited by PubMed Abstract: The NMR structure of the severe acute respiratory syndrome coronavirus nonstructural protein (nsp) 7 in aqueous solution at pH 6.5 was determined and compared with the results of previous structure determinations of nsp7 in solution at pH 7.5 and in the crystals of a hexadecameric nsp7/nsp8 complex obtained from a solution at pH 7.5. All three structures contain four helices as the only regular secondary structures, but there are differences in the lengths and sequence locations of the four helices, as well as between the tertiary folds. The present study includes data on conformational equilibria and intramolecular rate processes in nsp7 in solution at pH 6.5, which provide further insights into the polymorphisms implicated by a comparison of the three presently available nsp7 structures. PubMed: 20709084DOI: 10.1016/j.jmb.2010.07.043 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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